The mouse model is suitable for the study of viral factors governing transmission and pathogenesis of highly pathogenic avian influenza (HPAI) viruses in mammals
Identifieur interne : 000D86 ( Main/Exploration ); précédent : 000D85; suivant : 000D87The mouse model is suitable for the study of viral factors governing transmission and pathogenesis of highly pathogenic avian influenza (HPAI) viruses in mammals
Auteurs : Michela Rigoni ; Anna Toffan ; Elisabetta Viale ; Marzia Mancin ; Filippo Cilloni ; Elena Bertoli ; Angela Salomoni ; Sabrina Marciano ; Adelaide Milani ; Bianca Zecchin ; Ilaria Capua ; Giovanni CattoliSource :
- Veterinary Research [ 0928-4249 ] ; 2010.
English descriptors
Abstract
Highly pathogenic avian influenza (HPAI) viruses of the H5 and H7 subtype pose a major public health threat due to their capacity to cross the species barrier and infect mammals, for example dogs, cats and humans. In the present study we tested the capacity of selected H7 and H5 HPAI viruses to infect and to be transmitted from infected BALB/c mice to contact sentinels. Previous experiments have shown that viruses belonging to both H5 and H7 subtypes replicate in the respiratory tract and central nervous system of experimentally infected mice. In this study we show that selected H7N1 and H5N1 HPAI viruses can be transmitted from mouse-to-mouse by direct contact, and that in experimentally infected animals they exhibit a different pattern of replication and transmission. Our results can be considered as a starting point for transmission experiments involving other influenza A viruses with α 2-3 receptor affinity in order to better understand the viral factors influencing transmissibility of these viruses in selected mammalian species.
Url:
DOI: 10.1051/vetres/2010038
Affiliations:
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last="Salomoni">Angela Salomoni</name></author><author><name sortKey="Marciano, Sabrina" sort="Marciano, Sabrina" uniqKey="Marciano S" first="Sabrina" last="Marciano">Sabrina Marciano</name></author><author><name sortKey="Milani, Adelaide" sort="Milani, Adelaide" uniqKey="Milani A" first="Adelaide" last="Milani">Adelaide Milani</name></author><author><name sortKey="Zecchin, Bianca" sort="Zecchin, Bianca" uniqKey="Zecchin B" first="Bianca" last="Zecchin">Bianca Zecchin</name></author><author><name sortKey="Capua, Ilaria" sort="Capua, Ilaria" uniqKey="Capua I" first="Ilaria" last="Capua">Ilaria Capua</name></author><author><name sortKey="Cattoli, Giovanni" sort="Cattoli, Giovanni" uniqKey="Cattoli G" first="Giovanni" last="Cattoli">Giovanni Cattoli</name></author></analytic><idno type="DOI">10.1051/vetres/2010038</idno><series><title level="j">Veterinary Research</title><idno type="ISSN">0928-4249</idno><imprint><date 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In the present study we tested the capacity of selected H7 and H5 HPAI viruses to infect and to be transmitted from infected BALB/c mice to contact sentinels. Previous experiments have shown that viruses belonging to both H5 and H7 subtypes replicate in the respiratory tract and central nervous system of experimentally infected mice. In this study we show that selected H7N1 and H5N1 HPAI viruses can be transmitted from mouse-to-mouse by direct contact, and that in experimentally infected animals they exhibit a different pattern of replication and transmission. Our results can be considered as a starting point for transmission experiments involving other influenza A viruses with α 2-3 receptor affinity in order to better understand the viral factors influencing transmissibility of these viruses in selected mammalian species.</p> </div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bertoli, Elena" sort="Bertoli, Elena" uniqKey="Bertoli E" first="Elena" last="Bertoli">Elena Bertoli</name><name sortKey="Capua, Ilaria" sort="Capua, Ilaria" uniqKey="Capua I" first="Ilaria" last="Capua">Ilaria Capua</name><name sortKey="Cattoli, Giovanni" sort="Cattoli, Giovanni" uniqKey="Cattoli G" first="Giovanni" last="Cattoli">Giovanni Cattoli</name><name sortKey="Cilloni, Filippo" sort="Cilloni, Filippo" uniqKey="Cilloni F" first="Filippo" last="Cilloni">Filippo Cilloni</name><name sortKey="Mancin, Marzia" sort="Mancin, Marzia" uniqKey="Mancin M" first="Marzia" last="Mancin">Marzia Mancin</name><name sortKey="Marciano, Sabrina" sort="Marciano, Sabrina" uniqKey="Marciano S" first="Sabrina" last="Marciano">Sabrina Marciano</name><name sortKey="Milani, Adelaide" sort="Milani, Adelaide" uniqKey="Milani A" first="Adelaide" last="Milani">Adelaide Milani</name><name sortKey="Rigoni, Michela" sort="Rigoni, Michela" uniqKey="Rigoni M" first="Michela" last="Rigoni">Michela Rigoni</name><name sortKey="Salomoni, Angela" sort="Salomoni, Angela" uniqKey="Salomoni A" first="Angela" last="Salomoni">Angela Salomoni</name><name sortKey="Toffan, Anna" sort="Toffan, Anna" uniqKey="Toffan A" first="Anna" last="Toffan">Anna Toffan</name><name sortKey="Viale, Elisabetta" sort="Viale, Elisabetta" uniqKey="Viale E" first="Elisabetta" last="Viale">Elisabetta Viale</name><name sortKey="Zecchin, Bianca" sort="Zecchin, Bianca" uniqKey="Zecchin B" first="Bianca" last="Zecchin">Bianca Zecchin</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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